Three major tips if you would like to win the 2048 game:

1. Keep the cell with the highest value in one ofthe corners. Personally, I prefer the bottom-right corner. In order to achieve this...
2. ... mostly use the RIGHT, and DOWN arrows.
3. Try to use the UP arrow only when the right column is full. Otherwise, you are risking the field with the highest value to escape the bottom-right corner.
4. Avoid the LEFT arrow. Do not use it unless there is no other move left.
5. Try to keep the right vertical column full.

That's it. There are multiple YouTube.com videos with users that apply this concept.

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